Preliminary Programme

10:00-13:00	Registration
11:30-12:00	Welcome by organisers
12:00-13:00	Keynote Lecture Alessandro Bonetti (AstraZeneca, Cambridge, United Kingdom) Turning junk into gems: long non-coding RNAs unlock new therapeutic horizons
13:00-14:00	Lunch sponsored by Companies
Session 1: RNA-Centered Gene Regulation and Genome Dynamics Chairs: Francesco Nicassio, Alessandro Bonetti
14:30-14:55	Valentina Fragliasso (AUSL-IRCCS, Reggio Emilia) The HELLS–MCM5 axis safeguards genomic stability and represents a therapeutic vulnerability in ALK-negative ALCL
14:55-15:20	Maxim Bouvet (University of Turin) WBSCR22-mediated m7G rRNA methylation promotes translational reprogramming and liver metastasis in uveal melanoma
15:20-15:45	Simone Ponzetto (IFOM, Milan) Detained Introns as a coding-region reservoir for rapid cell-fate switching
15:45-16:15	Coffee break
Session 2: Emerging RNA Platforms and Applied Technologies (featured by RNA SALON) Chairs: Francesco Nicassio, Ivano Legnini
16:15-17:00	Keynote Lecture Ivano Legnini (Human Technopole, Milan, Italy) Spatiotemporal regulation of gene expression: from description to perturbation and back
17:00-17:25	Christian Ramirez Amarilla(University of Trento) Decoding transcriptome-wide redistribution of m6A readers upon METTL3 inhibition using RNAEventProfiler
17:25-17:50	Annalisa Fico (Institute of Genetics and Biophysics “A. Buzzati-Traverso”, Naplese) Exploring suppressor tRNA–mediated modulation of translation in IRF2BPL disease models
17:50-18:40	Talks by companies Thomas Frischmuth (Baseclick Gmbh) Targeted RNA drug delivery - possible new treatment options Pierluigi Tenca (Tema Ricerca) SeekGene technologies: unlocking cellular heterogeneity and gene regulation mechanisms through high-throughput single-cell multi-omics Davide Merulla (Immagina) Translatomics the next big Omics: what it is, and which tools we have for studying it
18:40-20:30	Poster Session with drinks
20:30-23:30	Social dinner

Session 3: RNA regulation in Disease and Development Chairs: Alessia Ciarrocchi, Giorgio Galli
9:00-9:45	Keynote Lecture Giorgio Galli (Novartis, Basel, Switzerland) Functional genomics approaches to dissect oncogenic gene regulatory mechanisms
9:45-10:10	Martina Coco (University of Turin) miR-148b-dependent mitochondrial dysfunction impairs melanoma metastatic progression via PGC-1α/β direct targeting
10:10-10:35	Giada Tria (IIT, Milan) From chromatin maps to tumor plasticity: charting the regulatory logic of hybrid EMT states
10:35-11:00	Sara Napoli (USI, Bellinzona, Switzerland) Dynamic and isoform-specific functions of long noncoding RNA LINC00511 in shaping the adaptive responses to BCR inhibition in B-cell lymphomas
11:00-11:30	Coffee break
Session 4: Mapping RNA Structure and Functional Interactions Chairs: Roberto Giambruno, Danny Incarnato
11:30-12:15	Keynote Lecture Danny Incarnato (University of Groningen, The Netherlands) Mapping, functional characterization and therapeutic targeting of RNA structural ensembles in living cells
12:15-12:40	Elisa Cataudella (IGM-CNR, University of Pavia) A transiently amplifying and self-limiting NOVA2-ADAR2 circuit in endothelial cells
12:40-13:05	Ioannis Saitoglou (IIT, Genoa) Epitranscriptomic regulation of BRD4 transcriptional condensates and chromatin architecture
13:05-13:30	Beatrice Maffeo (Fond. IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan) Stress adaptation in splicing factor-mutant myeloid malignancies
13:30-14:00	Poster Prizes and Closing Remarks
14:00	Lunch box

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Poster Session • 23 October • 18:40-20:30

P.1 Pablo Angulo Lara (Milan)
Long-read sequencing uncovers allele-specific dosage compensation in aneuploidy

P.2 Maria Giusy Bruno (Verona)
From patient-derived midbrain organoids to minigene assays: dissecting PTBP1-dependent alternative splicing of MAPT and BIN1 in Parkinson's disease

P.3 Margherita Caputo (Milan)
Role of RNA and RNA-binding proteins in EGFR endocytosis

P.4 Claudia Castiglioni (Milan)
DDX6 controls hematopoietic and endothelial fate specification in a stage-specific manner

P.5 Cinzia Cocola (Segrate, MI)
Decoding stem cell commitment: codon usage and core-structural tRNA modifications regulate clonogenic potential in human keratinocytes

P.6 Rebecca Crivellari (Padua)
STAT3-dependent circular RNAs define symptomatic disease and therapeutic response in T-LGLL

P.7 Sofia Denaro (Milan)
Single-cell characterization of breast cancer patient-derived organoids reveals cellular plasticity and transcriptional diversity

P.8 Anna Di Matteo (Pavia)
Alternative splicing of ERK5 as a novel therapeutic vulnerability in cancer: characterization and pharmacological induction of the pro-apoptotic ΔN-ERK5 isoform

P.9 Ipek Erdogan-Vatansever (Izmir)
Investigation of intracellular localization of intronic RNAs in a triple-negative breast cancer model

P.10 Luca Fava (Trento)
Uncovering resistance to METTL3 inhibitors through massively parallel base editing

P.11 Chiara Finocchiaro (Milan)
The epigenetic logic underlying hybrid-EMT states in Triple Negative Breast Cancer

P.12 Giulia Fois (Milan)
Cap-trap full-length cDNA sequencing to decrypt the non-coding transcriptomic complexity of protein-coding loci

P.13 Michela Gagliardo (Palermo)
Analysis of miRNA exosomes cargo derived from amniotic mesenchymal stromal cells

P.14 Giulia Gambarelli (Reggio Emilia)
Chromatin remodeler HELLS and its cooperating transcription factors shape immune gene programs in ALK-Negative Anaplastic Large Cell Lymphoma

P.15 Sandini Garg (Genoa)
Small molecules acting on RNA targets in cancer (SMART-C)

P.16 Roberto Giambruno (Palermo)
The isolated HEPN domain of SACSIN exhibits RNA-binding activity

P.17 Alessandra Grieco (Modena)
EGLN1 dependency in KRAS-mutated lung cancer: beyond canonical HIF1α regulation to mitochondrial and chromatin remodeling

P.18 Mila Gugnoni (Reggio Emilia)
Linc00941 as a molecular architect of translational resilience and immune landscape remodeling in malignant pleural mesothelioma

P.19 Domenico Ignoti (Turin)
Metabolic CRISPR screen identifies novel synthetic lethal partner of TGS1 in Acute Myeloid Leukaemia

P.20 Fatemeh Kordevani (Milan)
Triple-Negative Breast Cancer characterization in cell lines and organoids using long-read sequencing

P.21 Andrea Claudio Li Greci (Palermo)
Splicing modulation through advanced RNA technologies: ASO design and validation for LMNA

P.22 Jiazhi Lin (Milan)
U2AF1 splicing factor mutation and Cajal bodies in myeloid malignancies

P.23 Selene Mallia (Reggio Emilia)
The lncRNA MTAAT orchestrates ARF6-dependent PD-L1 dynamics in T-Cell lymphoma with implications for immunotherapy

P.24 Veronica Manicardi (Reggio Emilia)
Mapping the lncRNA landscape to decode tumor-immune crosstalk in diffuse pleural mesothelioma

P.25 Tommaso Martinelli (Modena)
Role of NF-YA alternative splicing in early prostate epithelial cell transformation

P.26 Elena Messina (Rome)
Identification of a novel circRNA candidate linked to the adaptive resistant state in KRAS G12C-mutant lung adenocarcinoma

P.27 Maria Chiara Mottola (Pavia)
Distinct roles of LINP1-202 and LINP1-214 in supporting proliferation under chronic DNA damage

P.28 Sabela Nikolli (Rome)
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

P.29 Silvia Nostro (Milan)
Elucidating the role of transposable elements in the transcriptional regulation of cell heterogeneity

P.30 Cecilia Perrucci (Reggio Emilia)
Integrative spatial transcriptomics and digital RNA profiling reveal prognostic transcriptional signatures in classical Hodgkin lymphoma

P.31 Giulia Pertile (Padua)
Profiling of long non-coding RNAs (lncRNAs) identifies a disease-specific lncRNA signature in T-cell large granular lymphocyte leukemia (T-LGLL)

P.32 Miriam Piccioni (Naples)
A grapevine miRNA exerts “cross-kingdom” activity affecting cancer progression

P.33 Alessandro Pilli (Trento)
Multi-omic profiling reveals U2AF1-driven dysregulation of stress granules and translation

P.34 Alessandro Poletti (Milan)
Defining hybrid EMT regulatory networks in triple-negative breast cancer using single-cell multiomics

P.35 Elisa Rampazzo (Padua)
MiR-146b restoration in T-cell large granular lymphocyte leukemia (T-LGLL): selective molecular reprogramming toward an RNA-based targeted therapy

P.36 Matteo Rovere (Genoa)
Small non-coding RNA dysregulation in the microglia from a mouse model of down syndrome

P.37 Martina Scichilone (Segrate, MI)
Evaluation of the N⁶-methyladenosine (m⁶A) RNA modification pathway as a driver of tumor proliferation via high-throughput CRISPR screening

P.38 Giulia Solbiati (Milan)
LINE1 RNAs act as chromatin-associated antioxidants and promote chemoresistance

P.39 Carlotta Spattini (Genoa)
Extracellular vesicles-mediated miRNA release contributes to the depletion of intracellular miRNAs in specific subtypes of human medulloblastoma

P.40 Cecilia Studniarek (Milan)
Dynamic arginine methylation rewires RNA-binding proteins and translation during cisplatin-induced stress adaptation

P.41 Anja Tolic (Genoa)
Investigating the crosstalk between m6A and 3D chromatin architecture

P.42 Riccardo Varrica (Palermo)
Nonsense variant suppression in DMD: tissue-specific restoration of dystrophin by novel readthrough compounds

P.43 Rebecca Vezzani (Modena)
Uncovering MPM’s vulnerability: FOSL1 as a driver of tumor progression

P.44 Giulia Visani (Milan)
Spatial organization of the neural stem cell transcriptome

P.45 Emanuele Vitale (Reggio Emilia)
Cracking the code of anaplastic transition: RUNX2 drives thyroid cancer evolution via inflammatory gene activation

P.46 Nicola Zambrano (Naples)
Spatial silencing of exogenous mRNAs via miRNA-based DTEs (de-targeting elements) reveals vaccination-competent tissues and provides a rationiale for Cas9 de-immunization for gene therapy applications

P.47 Ettore Zapparoli (Milan)
Investigating the relationship between transcription and RNA regulation